Total synthesis of antimalarial diterpenoid (+)-kalihinol A.
نویسندگان
چکیده
Total synthesis of antimalarial diterpenoid (+)-kalihinol A, isolated from marine sponge Acanthella sp., is achieved. This total synthesis involves regioselective alkylation of an epoxide, construction of a tetrahydropyran ring by iodo-etherification, construction of a cis-decalin ring by intramolecular Diels-Alder reaction, isomerization of cis-decalin to trans-decalin, and subsequent functionalization of the trans-decalin ring.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 6 شماره
صفحات -
تاریخ انتشار 2012